Hepatic portal vein denervation impairs oral glucose tolerance but not exenatide's effect on glycemia.

@article{Ionut2014HepaticPV,
  title={Hepatic portal vein denervation impairs oral glucose tolerance but not exenatide's effect on glycemia.},
  author={Viorica Ionut and Ana Val{\'e}ria Barros de Castro and Orison O Woolcott and Darko Stefanovski and Malini S. Iyer and Josiane L. Broussard and Miguel A. Burch and Ram Elazary and Cathryn M Kolka and Hasmik J. Mkrtchyan and Isaac Asare Bediako and Richard N Bergman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 8},
  pages={E644-52}
}
The hepatoportal area is an important glucohomeostatic metabolic sensor, sensing hypoglycemia, hyperglycemia, and hormones such as glucagon-like peptide-1 (GLP-1). We have reported previously that activation of hepatoportal sensors by intraportal infusion of glucose and GLP-1 or by subcutaneous administration of GLP-1 receptor activator exenatide and of intraportal glucose improved glycemia independent of corresponding changes in pancreatic hormones. It is not clear whether this effect is… CONTINUE READING

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