Hepatic portal glucose infusions decrease food intake and increase food preference.

@article{Tordoff1986HepaticPG,
  title={Hepatic portal glucose infusions decrease food intake and increase food preference.},
  author={Michael G Tordoff and Mark I. Friedman},
  journal={The American journal of physiology},
  year={1986},
  volume={251 1 Pt 2},
  pages={R192-6}
}
We examined the contribution of experimental factors to the hepatic control of food intake. Rats with either hepatic portal or jugular catheters were infused four times with glucose (4.5 mg/min) and equitonic saline (2 ml/2 h). During the infusions their food contained nonnutritive chocolate or chicken flavor, depending on the infusate received. Hepatic portal glucose decreased food intake relative to saline and no infusion conditions, but jugular glucose did not. When allowed to choose between… CONTINUE READING

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