Hepatic platelet and leukocyte adherence during endotoxemia

  title={Hepatic platelet and leukocyte adherence during endotoxemia},
  author={Roland Croner and Elfie Hoerer and Yakup Kulu and Tilo Hackert and M S Gebhard and Christian Herfarth and Ernst Klar},
  journal={Critical Care},
  pages={R15 - R15}
INTRODUCTION Liver microcirculation disturbances are a cause of hepatic failure in sepsis. Increased leukocyte-endothelial interaction, platelet adherence and impaired microperfusion cause hepatocellular damage. The time course and reciprocal influences of ongoing microcirculatory events during endotoxemia have not been clarified. METHODS Male Wistar rats (232 +/- 17 g) underwent cecal ligation and puncture (CLP). Intravital microscopy (IVM) was performed 0, 1, 3, 5, 10 and 20 hours after CLP… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 34 extracted citations

New directions for sepsis and septic shock research.

The Journal of surgical research • 2015
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 31 references

Effect of endotoxemia on hepatic portal and sinusoidal blood flow in rats

A Secchi, JM Ortanderl, +3 authors H Schmidt
J Surg Res • 2000
View 13 Excerpts
Highly Influenced

The hepatic microvascular responses to sepsis.

Seminars in thrombosis and hemostasis • 2000
View 12 Excerpts
Highly Influenced

Functions of selectins.

Results and problems in cell differentiation • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…