Hepatic platelet and leukocyte adherence during endotoxemia

@article{Croner2006HepaticPA,
  title={Hepatic platelet and leukocyte adherence during endotoxemia},
  author={Roland Croner and Elfie Hoerer and Yakup Kulu and Tilo Hackert and M S Gebhard and Christian Herfarth and Ernst Klar},
  journal={Critical Care},
  year={2006},
  volume={10},
  pages={R15 - R15}
}
INTRODUCTION Liver microcirculation disturbances are a cause of hepatic failure in sepsis. Increased leukocyte-endothelial interaction, platelet adherence and impaired microperfusion cause hepatocellular damage. The time course and reciprocal influences of ongoing microcirculatory events during endotoxemia have not been clarified. METHODS Male Wistar rats (232 +/- 17 g) underwent cecal ligation and puncture (CLP). Intravital microscopy (IVM) was performed 0, 1, 3, 5, 10 and 20 hours after CLP… CONTINUE READING

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