Hepatic one-carbon metabolism in early folate deficiency in rats.

  title={Hepatic one-carbon metabolism in early folate deficiency in rats.},
  author={M Balaghi and Donald W Horne and Conrad Wagner},
  journal={The Biochemical journal},
  volume={291 ( Pt 1)},
Glycine N-methyltransferase (GNMT) is inhibited by 5-methyltetrahydrofolate polyglutamate in vitro. It is believed to play a regulatory role in the synthesis de novo of methyl groups. We have used the amino-acid-defined diet of Walzem and Clifford [(1988) J. Nutr. 118, 1089-1096] to determine whether folate deficiency in vivo would affect GNMT activity, as predicted by the studies in vitro. Weanling male rats were fed on the folate-deficient diet or a folate-supplemented diet pair-fed to the… CONTINUE READING
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