Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.

@article{Burhans2015HepaticOR,
  title={Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.},
  author={Maggie S. Burhans and Matthew T. Flowers and Kristin R V Harrington and Laura M Bond and Chang-An Guo and Rozalyn M. Anderson and James M. Ntambi},
  journal={Journal of lipid research},
  year={2015},
  volume={56 2},
  pages={
          304-18
        }
}
Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) and protects against diet-induced hepatic steatosis and adiposity. To understand the mechanism by which hepatic MUFA production influences adipose tissue stores, we created two liver-specific transgenic mouse models in the SCD1 knockout that express… CONTINUE READING

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