Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury.

@article{Ramaiah2007HepaticNI,
  title={Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury.},
  author={Shashi K. Ramaiah and Hartmut Jaeschke},
  journal={Toxicology mechanisms and methods},
  year={2007},
  volume={17 7},
  pages={431-40}
}
ABSTRACT The histopathologic evidence of the presence of neutrophils within the liver parenchyma is a prominent feature of alcoholic hepatitis in both experimental animals and chronic human alcoholics. However, the precise mechanisms by which neutrophils infiltrate the liver and cause liver injury still remain to be fully elucidated. For neutrophils to infiltrate the liver, they have to undergo systemic activation (priming) by proinflammatory cytokines, chemokines, complement factors, and other… CONTINUE READING

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