Hepatic natural killer T‐cell and CD8+ T‐cell signatures in mice with nonalcoholic steatohepatitis

@inproceedings{Bhattacharjee2017HepaticNK,
  title={Hepatic natural killer T‐cell and CD8+ T‐cell signatures in mice with nonalcoholic steatohepatitis},
  author={Jashdeep Bhattacharjee and Michelle Rene Kirby and Samir Softic and Lili Miles and Rosa‐Maria Salazar‐Gonzalez and Pranav Shivakumar and Rohit Kohli},
  booktitle={Hepatology communications},
  year={2017}
}
Hepatic inflammation is a key pathological feature of Nonalcoholic Steatohepatitis (NASH). Natural Killer T-cells (NKT) and CD8+ T-cells are known to play an important role in obesity related adipose tissue inflammation. We hypothesized that these same inflammatory phenotypes would be present in progressive NASH. We used a previously established high fat high carbohydrate (HFHC) murine obesogenic diet model of progressive NASH to investigate the role of NKT cells and CD8+ T-cells in C57Bl6/J… CONTINUE READING
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