Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats.

@article{Hirano1992HepaticMG,
  title={Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats.},
  author={Tadamichi Hirano and Neil Kaplowitz and Hide Tsukamoto and Shoji Kamimura and Jos{\'e} C Fern{\'a}ndez-Checa},
  journal={Hepatology},
  year={1992},
  volume={16 6},
  pages={
          1423-7
        }
}
Long-term ethanol feeding has been shown to selectively reduce hepatic mitochondrial glutathione content by impairing mitochondrial uptake of this thiol. In this study, we assessed the role of this defect in evolution of alcoholic liver disease by examining the mitochondrial glutathione pool and lipid peroxidation during progression of experimental alcoholic liver disease to centrilobular liver necrosis and fibrosis. Male Wistar rats were intragastrically infused with a high-fat diet plus… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

Glutathione deficiency attenuates endotoxic fever in rats.

  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND