Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo.

@article{Lieber1970HepaticME,
  title={Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo.},
  author={Charles S. Lieber and Leonore M Decarli},
  journal={The Journal of biological chemistry},
  year={1970},
  volume={245 10},
  pages={2505-12}
}
A hepatic microsomal ethanol-oxidizing system is described both in men and rats. It is distinguished from alcohol dehydrogenase by its subcellular localization (cytosol for alcohol dehydrogenase, microsomes for this system), its pH optimum (physiological pH versus pH 10 to 11 for alcohol dehydrogenase), and its cofactor requirements (NADPH versus NAD+ for alcohol dehydrogenase). It also requires oxygen and is inhibited by CO, properties commonly found among microsomal drug-detoxifying enzymes… CONTINUE READING
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