Hepatic microsomal drug oxidation and electron transport in newborn infants.

@article{Aranda1974HepaticMD,
  title={Hepatic microsomal drug oxidation and electron transport in newborn infants.},
  author={Jacob V. Aranda and Stuart M. Macleod and Kenneth W. Renton and Norman R. Eade},
  journal={The Journal of pediatrics},
  year={1974},
  volume={85 4},
  pages={
          534-42
        }
}
Many drugs require oxidative metabolism for termination of action and/or for elimination from the body. Many oxidative reactions are catalyzed by hepatic microsomal enzymes. The activities of various drug-metabolizing enzymes, namely, NADPH cytochrome c reductase, NADPH oxidase, aminopyrine-N-demethylase, and analine P-hydroxylase, and the content of cytochrome P-450, were measured in hepatic microsomes obtained from seven newborn infants and four adult patients. The results in the newborn… CONTINUE READING

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