Hepatic microcirculation in fatty liver disease.

  title={Hepatic microcirculation in fatty liver disease.},
  author={Geoffrey C. Farrell and Narcissus C.‐H. Teoh and Robert S. McCuskey},
  journal={Anatomical record},
  volume={291 6},
Nonalcoholic fatty liver disease (NAFLD), the most common cause of steatosis, is associated with visceral obesity and insulin resistance. With more severe risk factors (obesity, type 2 diabetes [T2D], metabolic syndrome), steatosis may be complicated by hepatocellular injury and liver inflammation (steatohepatitis or NASH). NASH can lead to perisinusoidal fibrosis and cirrhosis. Fat-laden hepatocytes are swollen, and in steatohepatitis, further swelling occurs due to hydropic change (ballooning… CONTINUE READING
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