Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism.

@article{Chan1975HepaticMO,
  title={Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism.},
  author={Tze Ming Chan and Kenneth M. Young and N J Hutson and F T Brumley and John H. Exton},
  journal={The American journal of physiology},
  year={1975},
  volume={229 6},
  pages={1702-12}
}
Hepatic carbohydrate metabolism in genetically diabetic mice (db/db) and their normal littermates has been studied. In db/db mice, body water was below normal and declined with age. The liver of db/db mice was abnormally large in relation to the metabolic mass of the body at all ages studied. In db/db mice, hepatic glycogenolysis, glycogen synthesis, glycogen synthetase, and phosphorylase were markedly increased. Gluconeogenesis from alanine or lactate in perfused livers of db/db mice was… CONTINUE READING