Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.

@article{Bort1999HepaticMO,
  title={Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.},
  author={Roque Bort and Katherine Mac{\'e} and Alan R Boobis and M. Jos{\'e} G{\'o}mez-lech{\'o}n and Alexander Pfeifer and Jose V Castell},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 5},
  pages={787-96}
}
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor hydroxylated metabolites implicated in the idiosyncratic hepatotoxicity of the drug. Different experimental approaches were used: human hepatocytes, human microsomes, and engineered cells expressing single human CYP (cytochromes P450). Human hepatocytes formed 3'-hydroxy-, 4'-hydroxy-, 5-hydroxy- 4',5-dihydroxy-, and N,5-dihydroxydiclofenac, as well as several… CONTINUE READING
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