Hepatic metabolism of carcinogenic β-asarone.

  title={Hepatic metabolism of carcinogenic β-asarone.},
  author={Alexander Thomas Cartus and Simone Stegm{\"u}ller and Nadine Simson and Andrea Wahl and Sylvia K Neef and Harald Kelm and Dieter Schrenk},
  journal={Chemical research in toxicology},
  volume={28 9},
β-Asarone (1) belongs to the group of naturally occurring phenylpropenes like eugenol or anethole. Compound 1 is found in several plants, e.g., Acorus calamus or Asarum europaeum. Compound 1-containing plant materials and essential oils thereof are used to flavor foods and alcoholic beverages and as ingredients of many drugs in traditional phytomedicines. Although 1 has been claimed to have several positive pharmacological effects, it was found to be genotoxic and carcinogenic in rodents (liver… CONTINUE READING
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