Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis.

  title={Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis.},
  author={Shigang Xiong and Hongyun She and An-Sheng Zhang and Jiaohong Wang and Hasmik H. Mkrtchyan and Alla Dynnyk and Victor R Gordeuk and Samuel William French and Caroline A Enns and Hidekazu Tsukamoto},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={295 3},
One prime feature of alcoholic liver disease (ALD) is iron accumulation in hepatic macrophages/Kupffer cells (KC) associated with enhanced NF-kappaB activation. Our recent work demonstrates a peroxynitrite-mediated transient rise in intracellular labile iron (ILI) as novel signaling for endotoxin-induced IKK and NF-kappaB activation in rodent KC. The present study investigated the mechanism of KC iron accumulation and its effects on ILI response in experimental ALD. We also tested ILI response… CONTINUE READING
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Long-term phlebotomy with low-iron diet therapy lowers risk of G520 MACROPHAGE IRON SIGNALING AJP-Gastrointest Liver Physiol

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  • 2008
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