Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

@article{Friedman1985HepaticLT,
  title={Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.},
  author={Scott L Friedman and Frederick J Roll and J. D. Boyles and Daniel M. Bissell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 24},
  pages={8681-5}
}
Hepatic lipocytes were isolated from normal rat liver and established in culture. A virtually pure isolate was obtained by fractionating enzymatically digested liver on a discontinuous gradient of arabinogalactan. Isolated cells displayed prominent rough endoplasmic reticulum and typical cytoplasmic droplets containing vitamin A. Lipocytes in primary culture were shown by immunofluorescence to secrete collagen types I, III, and IV and also laminin. Immunoassay of culture media showed that… CONTINUE READING