Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.

@article{Croce2007HepaticL1,
  title={Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.},
  author={Michelle A. Croce and J. Christopher Eagon and Lori L. LaRiviere and Kevin M. Korenblat and Sulamita Klein and Brian N Finck},
  journal={Diabetes},
  year={2007},
  volume={56 9},
  pages={
          2395-9
        }
}
OBJECTIVE Lipin 1 plays critical roles in controlling energy metabolism. We sought to determine the expression of lipin 1 isoforms (lipin 1alpha and -beta) in liver and adipose tissue of obese subjects and to evaluate cellular mechanisms involved in the regulation of lipin 1 expression by physiologic stimuli. RESEARCH DESIGN AND METHODS The expression of lipin 1alpha and -beta was quantified in liver and adipose tissue of extremely obese (average BMI 60.8 kg/m(2)) human subjects undergoing… CONTINUE READING

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