Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1.

@article{Lambert1999HepaticLP,
  title={Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1.},
  author={Gilles Lambert and Michael B. Chase and Klaus A. Dugi and Andr{\'e} Bensadoun and Hollis B Brewer and Silvia Santamarina-Fojo},
  journal={Journal of lipid research},
  year={1999},
  volume={40 7},
  pages={1294-303}
}
Hepatic lipase (HL) plays a major role in high-density lipoprotein (HDL) metabolism both as a lipolytic enzyme and as a ligand. To investigate whether HL enhances the uptake of HDL-cholesteryl ester (CE) via the newly described scavenger receptor BI (SR-BI), we measured the effects of expressing HL and SR-BI on HDL-cell association as well as uptake of 125I-labeled apoA-I and [3H]CE-HDL, by embryonal kidney 293 cells. As expected, HDL cell association and CE selective uptake were increased in… CONTINUE READING
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