Hepatic lipase polymorphism and increased risk of peripheral arterial disease.

  title={Hepatic lipase polymorphism and increased risk of peripheral arterial disease.},
  author={Philipp Eller and Wilfried Schgoer and Thomas Mueller and Ivan Tancevski and Andreas Wehinger and Hanno Ulmer and Bernhard Foeger and Meinhard Haltmayer and Andreas Ritsch and Josef R. Patsch},
  journal={Journal of internal medicine},
  volume={258 4},
BACKGROUND Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties. We hypothesized single nucleotide polymorphisms in the promoter region of the hepatic lipase gene to be associated with an increased risk for peripheral arterial disease (PAD). METHODS A total of 241 patients with PAD and 241 controls matched for sex and age (+/-2 years) were genotyped cross-sectionally for… CONTINUE READING


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