Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.

Abstract

Coexistence of insulin resistance (IR) and metabolic syndrome (MetS) increases the risk of cardiovascular disease (CVD). Genetic studies in diabetes have linked Hepatic Lipase (HL) to an enhanced risk of CVD while others indicate a role of HL in inflammatory cells. Thus, we explored the role of HL on atherosclerosis and inflammation in a mouse model of MetS… (More)
DOI: 10.1160/TH15-10-0773

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Cite this paper

@article{AndrsBlasco2016HepaticLI, title={Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.}, author={Irene Andr{\'e}s-Blasco and {\'A}ngela Vinu{\'e} and Andrea Herrero-Cervera and Sergio Martinez-Hervas and Laura Dempsey Nunez and Laura Piqueras and Juan Francisco Ascaso and Mar{\'i}a Jes{\'u}s Pinar Sanz and Deborah Jane Burks and Herminia Gonz{\'a}lez-Navarro}, journal={Thrombosis and haemostasis}, year={2016}, volume={116 2}, pages={379-93} }