Hepatic lipase in the rat ovary. Ovaries cannot synthesize hepatic lipase but accumulate it from the circulation.

@article{Hixenbaugh1989HepaticLI,
  title={Hepatic lipase in the rat ovary. Ovaries cannot synthesize hepatic lipase but accumulate it from the circulation.},
  author={E A Hixenbaugh and Thomas R Sullivan and Jerome F Strauss and Elizabeth A Laposata and Miriam Komaromy and L G Paavola},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 7},
  pages={4222-30}
}
Hepatic lipase is proposed to have a role in steroidogenesis through its involvement in the metabolism of high density lipoproteins. We examined the activity, synthesis, distribution, and uptake of this enzyme and assessed the content of its mRNA in luteinized ovaries. We found that during peak steroidogenesis, ovaries of pregnant mare's serum gonadotropin-human chorionic gonadotropin-treated immature rats contained heparin-releasable hepatic lipase-like activity which was neutralized in a dose… CONTINUE READING
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