Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins.

  title={Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins.},
  author={T Y Thuren and Rebecca W. Wilcox and Patricia Sisson and Moseley Waite},
  journal={The Journal of biological chemistry},
  volume={266 8},
A monolayer technique was used to study the substrate specificity of hepatic lipase (HL) and the effect of surface pressure and apolipoproteins on hydrolysis of lipid monolayers by this enzyme. HL hydrolyzed readily phosphatidylethanolamine monolayers. Pure trioctanoylglycerol was found to be a poor substrate but when progressively diluted with nonhydrolyzable 1,2-didodecanoylphosphatidylcholine hydrolysis of triacylglycerol by HL reached maximum at a molar ratio of 1:1 triacylglycerol to… CONTINUE READING


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