Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease.

@article{Johannsen2009HepaticLG,
  title={Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease.},
  author={Trine Holm Johannsen and Pia R\orbœk Kamstrup and Rolf Vaern Andersen and Gorm Boje Jensen and H. Sillesen and Anne Tybjaerg-Hansen and B\orge G. Nordestgaard},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 4},
  pages={1264-73}
}
CONTEXT Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease). OBJECTIVE We tested the hypothesis that genetic variation in the hepatic lipase genetic variants V73M, N193S, S267F, L334F, T383M, and -480c>t influence levels of lipids, lipoproteins, and apolipoproteins and risk of ICD. DESIGN For the cross-sectional study, we genotyped 9003 individuals from… CONTINUE READING

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