Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis.

@article{Shiffman1994HepaticLM,
  title={Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis.},
  author={Mitchell L. Shiffman and Velimer A Luketic and Arun J Sanyal and Peter Duckworth and Preston P. Purdum and Melissa J. Contos and Alan Scott Mills and Leslie E. Edinboro and Alphonse Poklis},
  journal={Hepatology},
  year={1994},
  volume={19 4},
  pages={
          933-40
        }
}
Recent advances in the medical and surgical treatment of chronic hepatitis and cirrhosis have made it increasingly important to develop noninvasive tests of liver function. Our study has evaluated the hepatic conversion of lidocaine to its primary metabolite monoethylglycinexylodide and compared this with liver histological findings in 225 patients with chronic hepatitis (161 with hepatitis C, 23 with hepatitis B, 21 with autoimmune hepatitis and 20 with cryptogenic hepatitis). One hundred… CONTINUE READING
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