Hepatic levels of cyclosporine and metabolites in patients after liver transplantation.

@article{Lacerda1995HepaticLO,
  title={Hepatic levels of cyclosporine and metabolites in patients after liver transplantation.},
  author={Marco A. Lacerda and Larry D. Bowers and Dale C. Snover and William D. Payne and Joseph R. Bloomer},
  journal={Clinical transplantation},
  year={1995},
  volume={9 1},
  pages={35-8}
}
Despite the critical role of the liver in the metabolism of cyclosporine, only a few studies have measured hepatic levels (CSAH) in patients receiving the drug, and none has directly assayed hepatic levels of the metabolites. In this study we measured CSAH and its principal metabolites (mono-OH and di-OH CSA) by HPLC/mass spectroscopy in 19 liver biopsy specimens collected from 14 patients who had undergone liver transplantation, in order to determine how they correlated with blood levels (CSAB… CONTINUE READING