Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB.

@article{Hur1999HepaticII,
  title={Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB.},
  author={Gang Min Hur and Young Sue Ryu and H. Y. Yun and Byeong Hwa Jeon and Yong Man Kim and Jeong Ho Seok and Je Ho Lee},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 3},
  pages={917-22}
}
It has been known that many immediately early genes are expressed during ischemia/reperfusion (I/R) injury. Here, employing a model of hepatic I/R, we show that inducible nitric oxide synthase (iNOS) is induced via the activation of nuclear factor kappaB (NF-kappaB) after I/R in rat liver. When liver was subjected to ischemia followed by reperfusion, but not ischemia alone, an NF-kappaB complex composed of p50/p65 heterodimer and p50 homodimer was rapidly activated within 1 h and remained… CONTINUE READING