Hepatic iron overload in alcoholic end‐stage liver disease is associated with iron deposition in other organs in the absence of HFE‐1 hemochromatosis

@article{Eng2005HepaticIO,
  title={Hepatic iron overload in alcoholic end‐stage liver disease is associated with iron deposition in other organs in the absence of HFE‐1 hemochromatosis},
  author={Sue C. Eng and Shari L. Taylor and Victoria Reyes and Stuart Raaka and Jos{\'e} Berger and Kris V. Kowdley},
  journal={Liver International},
  year={2005},
  volume={25}
}
Background: End‐stage cirrhosis in the absence of hereditary hemochromatosis (HHC) can be associated with moderate to marked hepatic iron overload, especially in liver disease as a result of alcohol and/or hepatitis C. However, no published studies have addressed extrahepatic iron deposition in this setting. 
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References

SHOWING 1-10 OF 28 REFERENCES
Increased hepatic iron and cirrhosis: No evidence for an adverse effect on patient outcome following liver transplantation
TLDR
The data suggest that the severity of the liver disease rather than hepaticIron concentration is the most important determinant of outcome after liver transplantation and that, in general, increasing hepatic iron concentration in cirrhosis is a surrogate marker of the severityof the underlying liver disease.
A reappraisal of hepatic siderosis in patients with end-stage cirrhosis: practical implications for the diagnosis of hemochromatosis.
TLDR
The aim of this study was to describe the histologic pattern of iron distribution in end-stage cirrhosis due to various causes and to test the reliability of the hepatic iron index in excluding or confirming associated hemochromatosis in such a condition.
Iron overload in cirrhosis—HFE genotypes and outcome after liver transplantation
TLDR
Patients with severe hepatic explant iron overload undergoing LTx have a reduced survival compared to liver transplant recipients withoutExplant iron excess, and HFE gene mutations were uncommon in patients with hepaticExplant hemosiderosis.
[Secondary iron overload].
TLDR
To properly evaluate the iron overloading one must be able to appreciate the cumulative red blood cell transfusion volumes, and weighting and countingred blood cell units.
End-stage liver disease without hemochromatosis associated with elevated hepatic iron index.
TLDR
Genotyping for Cys 282 Tyr may provide the best method to identify hereditary hemochromatosis in the setting of end-stage liver disease and Serum transferrin saturation and hepatic iron index lack specificity.
A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
TLDR
A mutation in the gene encoding Solute Carrier family 11, member A3 (SLC11A3), also known as ferroportin, is associated with autosomal dominant hemochromatosis.
Measurements of iron status in patients with chronic hepatitis.
TLDR
In patients with chronic hepatitis in whom hereditary hemochromatosis is suspected, a liver biopsy should be performed with quantitation of hepatic iron and calculation of the hepaticIron index to confirm the diagnosis.
Secondary iron overload.
TLDR
The use of iron chelating agents in the management of transfusion-induced secondary iron overload is reviewed and guidelines are suggested for chelation therapy of chronically transfused adults with refractory anemias.
Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation.
TLDR
Spur cell haemolytic anaemia provides an alternative potential mechanism for the heavy iron loading and was present in six of the eight patients with heavy iron deposition and only one of the remaining patients.
Review article: haemochromatosis.
TLDR
Haemochromatosis is now recognized to be a complex genetic disease with probable significant environmental and genetic modifying factors and the use of phenotypic tests, such as serum transferrin-iron saturation, for initial screening avoids the problem of the identification of non-expressing homozygotes.
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