Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study.

@article{Chien1997HepaticID,
  title={Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study.},
  author={Rong-Nan Chien and Lu Jun Yang and Paul Yann Lin and Yun-Fan Liaw},
  journal={Hepatology},
  year={1997},
  volume={25 1},
  pages={103-7}
}
To evaluate the incidence, severity, and course of ketoconazole-associated hepatic injury, 211 patients with onychomycosis were randomized by a ratio of 2:1 to receive either ketoconazole (137 patients) or griseofulvin (74 patients). All of them were seronegative for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) and had no biochemical abnormality before therapy. The two groups were comparable in age, sex, and pretherapy liver biochemical tests. Liver biochemical tests… CONTINUE READING

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