Hepatic hyperplasia and cancer in rats: metabolic alterations associated with cell growth.

@article{Rao1997HepaticHA,
  title={Hepatic hyperplasia and cancer in rats: metabolic alterations associated with cell growth.},
  author={K Narasimha Rao and Mary S. Elm and richard. hawkins tim. kelly and N Subash Chandar and Edward Brady and B. Eswar Rao and Hishashi Shinozuka and Patricia K. Eagon},
  journal={Gastroenterology},
  year={1997},
  volume={113 1},
  pages={238-48}
}
BACKGROUND & AIMS We showed previously that the peroxisome proliferators di(2-ethylhexyl)phthalate (DEHP), clofibrate, and 4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxyl)acetamide (BR931) alter hepatic sex steroid metabolism and receptor expression during induction of hepatic hyperplasia and hepatocellular carcinoma (HCC) in rats. The aim of this study was to identify metabolic changes associated with cell growth during hyperplasia and HCC. METHODS Hepatic hyperplasia was… CONTINUE READING