Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.

@article{Yin2011HepaticHN,
  title={Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.},
  author={Liya Yin and Huiyan Ma and Xuemei Ge and Peter A. Edwards and Yanqiao Zhang},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 2},
  pages={328-36}
}
OBJECTIVE Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are associated with maturity-onset diabetes of the young and lipid disorders. However, the mechanisms underlying the lipid disorders are poorly understood. In this study, we determined the effect of acute loss or augmentation of hepatic HNF4α function on lipid homeostasis. METHODS AND RESULTS We generated an adenovirus expressing LacZ (Ad-shLacZ) or short hairpin RNA of Hnf4α (Ad-shHnf4α). Tail vain injection… CONTINUE READING