Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling.

@article{Yumet2006HepaticGH,
  title={Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling.},
  author={Gladys Yumet and Margaret L Shumate and D. Patrick Bryant and Charles H Lang and Robert N Cooney},
  journal={Critical care medicine},
  year={2006},
  volume={34 5},
  pages={1420-7}
}
OBJECTIVE During sepsis, a two- to four-fold increase in circulating growth hormone (GH) is seen with 40-50% reductions in plasma insulin-like growth factor (IGF)-I. The suppressors of cytokine signaling (SOCS), inhibitors of cytokine, and growth factor signaling via the janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway have been implicated in the development of hepatic GH resistance. In this study we examine the effects of sepsis on GH-induced IGF-I expression… CONTINUE READING
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