Hepatic glutathione suppression by the alpha-adrenoreceptor stimulating agents phenylephrine and clonidine.

@article{Harbison1991HepaticGS,
  title={Hepatic glutathione suppression by the alpha-adrenoreceptor stimulating agents phenylephrine and clonidine.},
  author={Raymond D. Harbison and Robert C. James and Stephen M Roberts},
  journal={Toxicology},
  year={1991},
  volume={69 3},
  pages={279-90}
}
The effects of alpha-adrenoreceptor stimulation on hepatic glutathione content were examined in ICR male mice using a selective alpha 1-adrenoreceptor stimulating agent, phenylephrine, and a selective alpha 2-adrenoreceptor stimulating drug, clonidine. Phenylephrine produced a dose-dependent depression in hepatic glutathione levels when administered by the intraperitoneal (i.p.) route, with a maximum extent of depression of approximately 30% occurring in both male and female mice. Phenylephrine… CONTINUE READING