Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action.

@article{Guarino2003HepaticGA,
  title={Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action.},
  author={Maria Pedro Sucena Guarino and Ricardo Alexandre Afonso and Nuno Raimundo and Jo{\~a}o Filipe Raposo and M Paula Macedo},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={284 4},
  pages={
          G588-94
        }
}
We tested the hypothesis that hepatic nitric oxide (NO) and glutathione (GSH) are involved in the synthesis of a putative hormone referred to as hepatic insulin-sensitizing substance HISS. Insulin action was assessed in Wistar rats using the rapid insulin sensitivity test (RIST). Blockade of hepatic NO synthesis with N(G)-nitro-l-arginine methyl ester (l-NAME, 1.0 mg/kg intraportal) decreased insulin sensitivity by 45.1 +/- 2.1% compared with control (from 287.3 +/- 18.1 to 155.3 +/- 10.1 mg… CONTINUE READING

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