Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.

  title={Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics.},
  author={Robert C. James and Douglas R. Goodman and Raymond D. Harbison},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={221 3},
Propoxyphene and morphine lowered hepatic glutathione and increased serum glutamic-pyruvic transaminase (SGPT) activity when administered to male mice. Maximal changes were seen at 3 to 6 hr after administration, but the effects lasted for as long as 18 hr. Morphine-induced hepatic changes potentiated both acetaminophen and cocaine-induced hepatotoxicity. Naltrexone, a narcotic antagonist, abolished the glutathione depletion produced by both propoxyphene and morphine, but did not alter the… CONTINUE READING
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