Hepatic glucose production and insulin sensitivity preceding diabetes in monkeys.

@article{Bodkin1989HepaticGP,
  title={Hepatic glucose production and insulin sensitivity preceding diabetes in monkeys.},
  author={Noni L. Bodkin and Bonnie L. Metzger and B. C. Hansen},
  journal={The American journal of physiology},
  year={1989},
  volume={256 5 Pt 1},
  pages={
          E676-81
        }
}
The purpose of this study was to identify the relationship between basal hepatic glucose production (HGP) and peripheral insulin sensitivity as assessed by the hyperinsulinemic euglycemic clamp prior to and during the development of non-insulin-dependent (type 2) diabetes mellitus in rhesus monkeys. Twenty-six male monkeys (Macaca mulatta), including normal animals and monkeys in various phases of the development of spontaneous obesity-associated type 2 diabetes were studied. Fasting plasma… CONTINUE READING

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