Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes.

@article{Dutta2003HepaticGE,
  title={Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes.},
  author={Ranjan Dutta and Uma Shankar Singh and Tong-Bin Li and Myriam Fornage and Baiyu Teng},
  journal={Atherosclerosis},
  year={2003},
  volume={169 1},
  pages={
          51-62
        }
}
Atherosclerosis is a complex disease that gene and environment interaction influences the progression of atherosclerotic lesion development. Our laboratory used mice lacking both the low density lipoprotein (LDL) receptor and Apobec1 genes (LDLR-/-Apobec1-/-, designated LDb) to investigate gene-gene interaction and the influence of an environmental factor (high-fat diet) on gene networks. LDb mice (males and females) at 5 months of age were fed a chow or high fat diet for 3-month. The mice on a… CONTINUE READING
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