Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition.

@article{SvegliatiBaroni2008HepaticFI,
  title={Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition.},
  author={Gianluca Svegliati-Baroni and Samuele de Minicis and Marco Marzioni},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2008},
  volume={28 8},
  pages={1052-64}
}
Hepatic fibrosis represents the wound-healing response process of the liver to chronic injury, independently from aetiology. Advanced liver fibrosis results in cirrhosis that can lead to liver failure, portal hypertension and hepatocellular carcinoma. Currently, no effective therapies are available for hepatic fibrosis. After the definition of hepatic stellate cells (HSCs) as the main liver extracellular matrix-producing cells in the 1980s, the subsequent decade was dedicated to determine the… CONTINUE READING

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