Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production.

Abstract

Innate immunity controls pathogen replication and spread. Yet, certain pathogens, such as Hepatitis C Virus (HCV), escape immune elimination and establish persistent infections that promote chronic inflammation and related diseases. Whereas HCV regulatory proteins that attenuate antiviral responses are known, those that promote inflammation and liver injury… (More)
DOI: 10.1016/j.molcel.2012.07.032

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