Hepatic drug clearance in chronic liver disease: Can we expect to find a universal, quantitative marker of hepatic function?

@article{Morgan1989HepaticDC,
  title={Hepatic drug clearance in chronic liver disease: Can we expect to find a universal, quantitative marker of hepatic function?},
  author={D. V. Morgan and R. Smallwood},
  journal={Hepatology},
  year={1989},
  volume={10}
}
  • D. V. Morgan, R. Smallwood
  • Published 1989
  • Medicine
  • Hepatology
  • Blood clearance of antipyrine, indocyanine green, and galactose were measured to evaluate the alterations of effective hepatic blood flow and hepatic intrinsic clearances in chronic liver diseases. Galactose blood clearance, which may be taken as effective hepatic blood flow, decreased by approximately 30% in patients with cirrhosis (12.49 ± 0.76 ml/min/kg; mean ± SE; n = 17) compared with normal subjects (18.17 ± 1.03 ml/min/kg; n = 5). In patients with cirrhosis, intrinsic clearances of… CONTINUE READING
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