Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.

@article{Graham2001HepaticDO,
  title={Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.},
  author={Mark J. Graham and Stanley T. Crooke and Kristina M Lemonidis and Hans J. Gaus and Michael V. Templin and Rosanne M. Crooke},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 3},
  pages={297-306}
}
The pharmacokinetics of ISIS 1082, a 21-base heterosequence phosphorothioate oligodeoxynucleotide, were characterized within rodent whole liver, and cellular and subcellular compartments. Cross-species comparisons were performed using Sprague-Dawley rat and CD-1 mouse strains. Although whole liver oligonucleotide deposition and the proportion of drug found within parenchymal and nonparenchymal cells were similar between the two rodent species as a function of both time and dose, dramatic… CONTINUE READING

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