Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans.

@article{BratuschMarrain1984HepaticDO,
  title={Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans.},
  author={P. Bratusch-Marrain and W. Waldh{\"a}usl and S. Gasic and A. Hofer},
  journal={Metabolism: clinical and experimental},
  year={1984},
  volume={33 2},
  pages={
          151-7
        }
}
To examine the fate of insulin across the liver bed, biosynthetic human insulin was infused in increasing amounts in six healthy men. Trapping of insulin by the liver was determined by means of the hepatic venous catheter technique. To minimize any possible error in the estimation of insulin removal as a result of endogenous insulin, pancreatic insulin secretion was suppressed by intravenous administration of somatostatin (500 micrograms/h). Infusion rates of human insulin were 30, 60, and 150… Expand
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