Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice.

@article{Basford2011HepaticDO,
  title={Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice.},
  author={Joshua E. Basford and Lauren M. Wancata and Susanna M. Hofmann and R. A. Gangani D. Silva and W. Sean Davidson and Philip N. Howles and David Y Hui},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 15},
  pages={
          13079-87
        }
}
The low density lipoprotein receptor-related protein-1 (LRP1) is known to serve as a chylomicron remnant receptor in the liver responsible for the binding and plasma clearance of apolipoprotein E-containing lipoproteins. Previous in vitro studies have provided evidence to suggest that LRP1 expression may also influence high density lipoprotein (HDL) metabolism. The current study showed that liver-specific LRP1 knock-out (hLrp1(-/-)) mice displayed lower fasting plasma HDL cholesterol levels… CONTINUE READING
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