Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level

@article{Bartee2006HepaticCA,
  title={Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level},
  author={Mee Y. Bartee and Svetlana Lutsenko},
  journal={BioMetals},
  year={2006},
  volume={20},
  pages={627-637}
}
Copper-transporting ATPase ATP7B (Wilson disease protein) is a member of the P-type ATPase family with characteristic domain structure and distinct ATP-binding site. ATP7B plays a central role in the regulation of copper homeostasis in the liver by delivering copper to the secretory pathway and mediating export of excess copper into the bile. The dual function of ATP7B in hepatocytes is coupled with copper-dependent intracellular relocalization of the transporter. The final destination of ATP7B… CONTINUE READING