Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging

@article{BrileySaebo2004HepaticCD,
  title={Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging},
  author={Karen C. Briley-Saebo and A. F. Bj\ornerud and Derek Grant and H{\aa}kan Ahlstrom and Trond Berg and Grete M\ork Kindberg},
  journal={Cell and Tissue Research},
  year={2004},
  volume={316},
  pages={315-323}
}
The purpose of this study was to determine the cellular distribution and degradation in rat liver following intravenous injection of superparamagnetic iron oxide nanoparticles used for magnetic resonance imaging (NC100150 Injection). Relaxometric and spectrophotometric methods were used to determine the concentration of the iron oxide nanoparticles and their degradation products in isolated rat liver parenchymal, endothelial and Kupffer cell fractions. An isolated cell phantom was also… CONTINUE READING
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