Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis.

@article{Westra1981HepaticAR,
  title={Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis.},
  author={Peter Westra and Griejanne Vermeer and A R de Lange and Arnold H. J. Scaf and Dirk K. F. Meijer and H. W. M. Wesseling},
  journal={British journal of anaesthesia},
  year={1981},
  volume={53 4},
  pages={
          331-8
        }
}
The plasma clearance of pancuronium in patients with extrahepatic cholestasis was 16% lower than in a control group (1.47 +/- 0.11 ml min-1 kg-1 v. 1.76 +/- 0.21 ml min-1 kg-1), but the difference was not significant. A significant increase in the elimination half-life T 1/2 beta of pancuronium (from 141 to 224 min) and a significant increase in the volume of the peripheral compartment (V2) was found in patients with extrahepatic cholestasis when compared with control patients. There was a… CONTINUE READING

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