Hepatic and intestinal changes in rats treated with T-0126, a microsomal triglyceride transfer protein (mtp) inhibitor.

@article{Miyazaki2007HepaticAI,
  title={Hepatic and intestinal changes in rats treated with T-0126, a microsomal triglyceride transfer protein (mtp) inhibitor.},
  author={Miyazaki and Satoko Miwa and Hirohiko Kodama and Harutami Yamada and Koichi Nagata and Wataru Toriumi and Kazuyuki Kitamura and Eisuke Kume},
  journal={The Journal of toxicological sciences},
  year={2007},
  volume={32 2},
  pages={161-77}
}
In the present study, we investigated the potential toxic effects of 2-week oral treatment with T-0126, a novel microsomal triglyceride transfer protein (MTP) inhibitor, on the liver and intestine in male and female rats. Administration of T-0126 decreased serum lipids and resulted in fat accumulation in the liver and the small intestine. In addition… CONTINUE READING