Hepatic and extrahepatic metabolism of salbutamol in anesthetized rabbits.

@article{Perreault1993HepaticAE,
  title={Hepatic and extrahepatic metabolism of salbutamol in anesthetized rabbits.},
  author={Sylvie Perreault and Louis Dumont and V Villi{\`e}re and H W Ong and Aishah Adam and Patrick du Souich},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1993},
  volume={21 3},
  pages={485-91}
}
Orally administered salbutamol undergoes an extensive first-pass effect. This study investigated the roles of the intestine (INT), liver (HEP), and lung (LUN) in salbutamol extraction. Salbutamol was administered to five groups of anesthetized rabbits by the following routes: intraduodenal (ID) (800 micrograms/kg), intraportal (IP), (60 micrograms/kg), intrajugular (IV) (60 micrograms/kg), endotracheal (ET) (60 micrograms/kg), and intraarterial (IA) (60 micrograms/kg). Multiple blood samples… CONTINUE READING

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