Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells

@article{Okabe2010HepaticSC,
  title={Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells},
  author={Hirohisa Okabe and Toru Beppu and Hiromitsu Hayashi and Takatoshi Ishiko and Toshiro Masuda and Ryu Otao and Hasita Horlad and Hirohumi Jono and Mitsuharu Ueda and Satoru Shinriki and Yukio Ando and Hideo Baba},
  journal={Annals of Surgical Oncology},
  year={2010},
  volume={18},
  pages={1175-1184}
}
Although tumor–stromal interaction has been discussed, the role of hepatic stellate (HS) cells against cancer, especially cholangiocarcinoma (CC), has not been clarified. The aim of this study is to investigate the effect of HS cells on CC cell progression in vitro and in vivo. The effects of CC conditioned medium (CC-CM) on activation and proliferation of HS cells (LI90 and LX-2), the influences of HS cell CM (HS-CM) on proliferation and invasion of CC cells (HuCCT-1 and RBE), and the effects… CONTINUE READING