Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.

@article{Qiang2015HepaticSG,
  title={Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.},
  author={Li Qiang and Ning Kon and Wenhui Zhao and Le Jiang and Colette M. Knight and Carrie L. Welch and Utpal B. Pajvani and Wei Gu and Domenico Accili},
  journal={Cell reports},
  year={2015},
  volume={11 11},
  pages={1797-808}
}
Obesity is associated with higher incidence of cancer, but the predisposing mechanisms remain poorly understood. The NAD(+)-dependent deacetylase SirT1 orchestrates metabolism, cellular survival, and growth. However, there is no unifying mechanism to explain the metabolic and tumor-related effects of SirT1. In this work, we demonstrate that genetic ablation of the endogenous inhibitor of SirT1, Deleted-in-Breast-Cancer-1 (Dbc1), unexpectedly results in obesity and insulin resistance. Dbc1… CONTINUE READING
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