Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance.

@article{Kim2015HepaticSA,
  title={Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance.},
  author={Hye Young Kim and So Youn Park and Mi Hwa Lee and Jee Hyun Rho and Yoo Oh and Hye Uk Jung and Seung Hee Yoo and Na Young Jeong and Hye Jeong Lee and Sunghwan Suh and Su Yeong Seo and Jaehun Cheong and Jin Sook Jeong and Young Hyun Yoo},
  journal={Journal of hepatology},
  year={2015},
  volume={63 2},
  pages={
          477-85
        }
}
BACKGROUND & AIMS Most studies on the role of STAMP2 in metabolism have used adipose tissue. Little knowledge exists concerning the role of STAMP2 in the liver, which is a metabolically central target. We hypothesized that STAMP2 is involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. METHODS We examined our hypothesis using human NAFLD patient pathology samples and a high-fat diet (HFD)-induced NAFLD mouse model. The molecular mechanism underlying hepatic STAMP2-mediated lipid… CONTINUE READING
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